FSI’s researchers assess health and medicine through the lenses of economics, nutrition and politics. They’re studying and influencing public health policies of local and national governments and the roles that corporations and nongovernmental organizations play in providing health care around the world. Scholars look at how governance affects citizens’ health, how children’s health care access affects the aging process and how to improve children’s health in Guatemala and rural China. They want to know what it will take for people to cook more safely and breathe more easily in developing countries.
FSI professors investigate how lifestyles affect health. What good does gardening do for older Americans? What are the benefits of eating organic food or growing genetically modified rice in China? They study cost-effectiveness by examining programs like those aimed at preventing the spread of tuberculosis in Russian prisons. Policies that impact obesity and undernutrition are examined; as are the public health implications of limiting salt in processed foods and the role of smoking among men who work in Chinese factories. FSI health research looks at sweeping domestic policies like the Affordable Care Act and the role of foreign aid in affecting the price of HIV drugs in Africa.
Stanford law professor, security expert to lead FSI
Mariano-Florentino Cuéllar, a Stanford law professor and expert on administrative law and governance, public organizations, and transnational security, will lead the university’s Freeman Spogli Institute for International Studies.
The announcement was made in Feb. 11 by Provost John Etchemendy and Ann Arvin, Stanford’s vice provost and dean of research.
“Professor Cuéllar brings a remarkable breadth of experience to his new role as FSI director, which is reflected in his many achievements as a legal scholar and his work on diverse federal policy initiatives over the past decade,” Arvin said. “He is deeply committed to enhancing FSI’s academic programs and ensuring that it remains an intellectually rich environment where faculty and students can pursue important interdisciplinary and policy-relevant research.”
Known to colleagues as “Tino,” Cuéllar starts his role as FSI director on July 1.
Cuéllar has been co-director of FSI’s Center for International Security and Cooperation (CISAC) since 2011, and has served in the Clinton and Obama administrations. In his role as FSI director, he’ll oversee 11 research centers and programs – including CISAC – along with a variety of undergraduate and graduate education initiatives on international affairs. His move to the institute's helm will be marked by a commitment to build on FSI’s interdisciplinary approach to solving some of the world’s biggest problems.
“I am deeply honored to have been asked to lead FSI. The institute is in a unique position to help address some of our most pressing international challenges, in areas such as governance and development, health, technology, and security,” Cuéllar said. “FSI’s culture embodies the best of Stanford – a commitment to rigorous research, training leaders and engaging with the world – and excels at bringing together accomplished scholars from different disciplines.”
Cuéllar, 40, is a senior fellow at FSI and the Stanley Morrison Professor of Law at the law school, where he will continue to teach and conduct research. He succeeds Gerhard Casper, Stanford’s ninth president and a senior fellow at FSI.
“We are deeply indebted to former President Casper for accomplishing so much as FSI director this year and for overseeing the transition to new leadership so effectively,” Arvin said.
Casper was appointed to direct the institute for one year following the departure of Coit D. Blacker, who led FSI from 2003 to 2012 and oversaw significant growth in faculty appointments and research.
Casper, who chaired the search for a new director, said Cuéllar has a “profound understanding of institutions and policy issues, both nationally and internationally.”
“Stanford is very fortunate to have persuaded Tino to become director of the Freeman Spogli Institute for International Studies,” Casper said. “He will not only be an outstanding fiduciary of the institute, but with his considerable imagination, energy, and tenacity will develop collaborative and multidisciplinary approaches to problem-solving.”
Cuéllar – who did undergraduate work at Harvard, earned his law degree from Yale and received his PhD in political science at Stanford in 2000 – has had an extensive public service record since he began teaching at Stanford Law School in 2001.
Taking a leave of absence from Stanford during 2009 and 2010, he worked as special assistant to the president for justice and regulatory policy at the White House, where his responsibilities included justice and public safety, public health policy, borders and immigration, and regulatory reform. Earlier, he co-chaired the presidential transition team responsible for immigration.
After returning to Stanford, he accepted a presidential appointment to the Council of the Administrative Conference of the United States, a nonpartisan agency charged with recommending improvements in the efficiency and fairness of federal regulatory programs.
Cuéllar also worked in the Treasury Department during the Clinton administration, focusing on fighting financial crime, improving border coordination and enhancing anti-corruption measures.
Since his appointment as co-director of CISAC, Cuéllar worked to expand the center’s agenda while continuing its strong focus on arms control, nuclear security and counterterrorism. During Cuéllar’s tenure, the center launched new projects on cybsersecurity, migration and refugees, as well as violence and governance in Latin America. CISAC also added six fellowships; recruited new faculty affiliates from engineering, medicine, and the social sciences; and forged ties with academic units across campus.
He said his focus as FSI’s director will be to strengthen the institute’s centers and programs and enhance its contributions to graduate education while fostering collaboration among faculty with varying academic backgrounds.
“FSI has much to contribute through its existing research centers and education programs,” he said. “But we will also need to forge new initiatives cutting across existing programs in order to understand more fully the complex risks and relationships shaping our world.”
In addition to Casper, the members of the search committee were Michael H. Armacost, Francis Fukuyama, Philip W. Halperin, David Holloway, Rosamond L. Naylor, Douglas K. Owens, and Elisabeth Paté-Cornell.
Towards a Global Neuroindustry: What About the Human Being That We Know?
Five foreign policy questions for Obama and Romney
President Obama and Mitt Romney meet for their third debate to discuss foreign policy on Monday, when moderator Bob Schieffer is sure to ask them about last month's terrorist attack in Libya and the nuclear capabilities of Iran.
In anticipation of the final match between the presidential candidates, researchers from five centers at Stanford’s Freeman Spogli Institute for International Studies ask the additional questions they want answered and explain what voters should keep in mind.
What can we learn from the Arab Spring about how to balance our values and our interests when people in authoritarian regimes rise up to demand freedom?
What to listen for: First, the candidates should address whether they believe the U.S. has a moral obligation to support other peoples’ aspirations for freedom and democracy. Second, they need to say how we should respond when longtime allies like Egypt’s Hosni Mubarak confront movements for democratic change.
And that leads to more specific questions pertaining to Arab states that the candidates need to answer: What price have we paid in terms of our moral standing in the region by tacitly accepting the savage repression by the monarchy in Bahrain of that country's movement for democracy and human rights? How much would they risk in terms of our strategic relationship with Bahrain and Saudi Arabia by denouncing and seeking to restrain this repression? What human rights and humanitarian obligations do we have in the Syrian crisis? And do we have a national interest in taking more concrete steps to assist the Syrian resistance? On the other hand, how can we assist the resistance in a way that does not empower Islamist extremists or draw us into another regional war?
Look for how the candidates will wrestle with difficult trade-offs, and whether either will rise above the partisan debate to recognize the enduring bipartisan commitment in the Congress to supporting democratic development abroad. And watch for some sign of where they stand on the spectrum between “idealism” and “realism” in American foreign policy. Will they see that pressing Arab states to move in the direction of democracy, and supporting other efforts around the world to build and sustain democracy, is positioning the United States on “the right side of history”?
~Larry Diamond, director of the Center on Democracy, Development, and the Rule of Law
What do you consider to be the greatest threats our country faces, and how would you address them in an environment of profound partisan divisions and tightly constrained budgets?
What to listen for: History teaches that some of the most effective presidential administrations understand America's external challenges but also recognize the interdependence between America's place in the world and its domestic situation.
Accordingly, Americans should expect their president to be deeply knowledgeable about the United States and its larger global context, but also possessed of the vision and determination to build the country's domestic strength.
The president should understand the threats posed by nuclear proliferation and terrorist organizations. The president should be ready to lead in managing the complex risks Americans face from potential pandemics, global warming, possible cyber attacks on a vulnerable infrastructure, and failing states.
Just as important, the president needs to be capable of leading an often-polarized legislative process and effectively addressing fiscal challenges such as the looming sequestration of budgets for the Department of Defense and other key agencies. The president needs to recognize that America's place in the world is at risk when the vast bulk of middle class students are performing at levels comparable to students in Estonia, Latvia and Bulgaria, and needs to be capable of engaging American citizens fully in addressing these shared domestic and international challenges.
~Mariano-Florentino Cuéllar, co-director of the Center for International Security and Cooperation
Should our government help American farmers cope with climate impacts on food production, and should this assistance be extended to other countries – particularly poor countries – whose food production is also threatened by climate variability and climate change?
What to listen for: Most representatives in Congress would like to eliminate government handouts, and many would also like to turn away from any discussion of climate change. Yet this year, U.S. taxpayers are set to pay up to $20 billion to farmers for crop insurance after extreme drought and heat conditions damaged yields in the Midwest.
With the 2012 farm bill stalled in Congress, the candidates need to be clear about whether they support government subsidized crop insurance for American farmers. They should also articulate their views on climate threats to food production in the U.S. and abroad.
Without a substantial crop insurance program, American farmers will face serious risks of income losses and loan defaults. And without foreign assistance for climate adaptation, the number of people going hungry could well exceed 15 percent of the world's population.
~Rosamond L. Naylor, director of the Center on Food Security and the Environment
What is your vision for the United States’ future relationship with Europe?
What to listen for: Between the end of World War II and the end of the Cold War, it was the United States and Europe that ensured world peace. But in recent years, it seems that “Europe” and “European” have become pejoratives in American political discourse. There’s been an uneasiness over whether we’re still friends and whether we still need each other. But of course we do.
Europe and the European Union share with the United States of America the most fundamental values, such as individual freedom, freedom of speech, freedom to live and work where you choose. There’s a shared respect of basic human rights. There are big differences with the Chinese, and big differences with the Russians. When you look around, it’s really the U.S. and Europe together with robust democracies such as Canada and Australia that have the strongest sense of shared values.
So the candidates should talk about what they would do as president to make sure those values are preserved and protected and how they would make the cooperation between the U.S. and Europe more effective and substantive as the world is confronting so many challenges like international terrorism, cyber security threats, human rights abuses, underdevelopment and bad governance.
~Amir Eshel, director of The Europe Center
Historical and territorial issues are bedeviling relations in East Asia, particularly among Japan, China, South Korea, and Southeast Asian countries. What should the United States do to try to reduce tensions and resolve these issues?
What to listen for: Far from easing as time passes, unresolved historical, territorial, and maritime issues in East Asia have worsened over the past few years. There have been naval clashes, major demonstrations, assaults on individuals, economic boycotts, and harsh diplomatic exchanges. If the present trend continues, military clashes – possibly involving American allies – are possible.
All of the issues are rooted in history. Many stem from Imperial Japan’s aggression a century ago, and some derive from China’s more assertive behavior toward its neighbors as it continues its dramatic economic and military growth. But almost all of problems are related in some way or another to decisions that the United States took—or did not take—in its leadership of the postwar settlement with Japan.
The United States’ response to the worsening situation so far has been to declare a strategic “rebalancing” toward East Asia, aimed largely at maintaining its military presence in the region during a time of increasing fiscal constraint at home. Meanwhile, the historic roots of the controversies go unaddressed.
The United States should no longer assume that the regional tensions will ease by themselves and rely on its military presence to manage the situation. It should conduct a major policy review, aimed at using its influence creatively and to the maximum to resolve the historical issues that threaten peace in the present day.
~David Straub, associate director of the Korea Studies Program at the Walter H. Shorentein Asia-Pacific Research Center
Compiled by Adam Gorlick.
Neuroculture: How to keep ethical pace with the current “deep” transformations through neurotechnology?
Stanford Interdisciplinary Conference on Conscience
Conference organizer: Nancy Ruttenburg
What is conscience, what was conscience, and what is its future?
The purpose of the conference is to examine the authority of conscience as it is presently invoked in various arenas of contemporary life—including law, medicine, journalism, and politics—and as its meaning is inflected by scholarly debates in the fields of history, literature, religious studies, psychology, and philosophy. From their various fields of expertise and interest, participants will address the central question the conference raises: in our post-Freudian and post-Nietzschean age, to what degree does conscience possess the kind of authority that an earlier and less secular age reserved for first things? This question entails a host of others. Do our invocations of conscience reveal it to be the still-vital residue of a kind of certainty linked to infallible authority from which we cannot alienate ourselves even when we’d like to? If so, is the enduring vitality of conscience a sign that the process of secularization remains incomplete, even in secular rationalists, those who might consider themselves to be exempt from the religiosity that distinguishes United States culture from those of other modern Western democracies? Do we regard conscience as a type of knowledge? Or is it possible to understand conscience ontologically, as a category of self or mind that—insofar as it speaks to all humanity by means of a "small, still voice" issuing from each human heart—bridges the gap between individual and corporate being? Whether or not underwritten by a discipline or a tradition, conscience is commonly invoked to justify a range of acts and behaviors: what relation do these invocations of moral law, even when unexamined, bear to the burgeoning interest in ethics we see across the humanities disciplines and into the legal, medical, and journalistic fields? Between the extremes of authoritarianism and anarchy, where do we place conscience in American political life and how do we understand its peculiar agency?
CONFERENCE VIDEO AND AUDIO RECORDINGS:
Please click on the panel titles and the keynote speaker's name below to view videos and listen to audios of each:
November 8, 2012
Panel 1: The Pre-Revolutionary Conscience: From Religious Burden to Natural Right (video)
Panel 2: MIA: Conscience and the First Amendment (video)
Panel 3: Roundtable: The Religious Conscience in Modernity (audio only)
Panel 4: Conscience/Ethics: The Secular Conscience (audio only)
November 9, 2012
Panel 5: Conscience and Reportage (video)
Panel 6: Roundtable: Embodied Conscience (video)
Panel 7: Roundtable: Conscientious Objection (video)
Keynote: Anne Aghion, award-winning documentary filmmaker (video)
PROGRAM AND PARTICIPANTS:
Opening Event: Wednesday, November 7, 6:00-8:30 p.m.
Screening of keynote speaker Anne Aghion’s documentary film, My Neighbor, My Killer, to be introduced by the filmmaker. Will be held in the Oksenberg Conference Room, Encina Hall Central, 3rd floor.
- 6:00 p.m. Reception
- 6:30 p.m. Screening
For more information on the film, please visit this event listing on our website by clicking <here>.
Thursday, November 8, 9:00 a.m. - 7:00 p.m:
Conscience and its Conceptual Evolution: Religion/Rights/Ethics
- 9:00 – 9:30 Opening Remarks: Nancy Ruttenburg, Organizer
Thursday Morning Panels: What Was Conscience? The American Context
- 9:30 – 11:30: The Pre-Revolutionary Conscience: From Religious Burden to Natural Right
1) Andrew Murphy, Associate Professor of Political Science, and Director of the Walt Whitman Center for the Culture and Politics of Democracy, Rutgers University, author of Conscience and Community: Revisiting Toleration and Religious Dissent in Early Modern England and America and Prodigal Nation: Moral Decline and Divine Punishment from New England to 9/11.
2) Mark Valeri, E. T. Thompson Professor of Church History, Union Presbyterian Seminary. Among the editors of the multi-volume Works of Jonathan Edwards, he is the author most recently of Heavenly Merchandize: How Religion Shaped Commerce in Puritan America.
Stanford Respondent: Caroline Winterer, Professor of History, Professor by courtesy of Classics
- 11:45 – 1:45: MIA: Conscience and the First Amendment
1) Jack Rakove, William Robertson Coe Professor of History and American Studies and Professor of Political Science at Stanford, where has taught since 1980. He is the author of six books, including Original Meanings: Politics and Ideas in the Making of the Constitution (1996), which received the Pulitzer Prize in History, and Revolutionaries: A New History of the Invention of America (2010), which was a finalist for the George Washington Prize. He is currently at work on Beyond Belief, Beyond Conscience: The Radical Significance of the Free Exercise of Religion, which will be part of the Oxford University Press series on Inalienable Rights.
2) Michael J. Perry, Robert W. Woodruff Professor of Law, and Senior Fellow for the Center for the Study of Law and Religion, Emory University School of Law. Author most recently of The Political Morality of Liberal Democracy; Constitutional Rights, Moral Controversy, and the Supreme Court; Toward a Theory of Human Rights: Religion, Law, Courts; and Under God?: Religious Faith and Liberal Democracy.
Stanford Respondent: Derek Webb, Fellow, Constitutional Law Center, Stanford
Thursday Afternoon Panels: What Is Conscience: The Secular/Religious Divide
- 2:45 – 4:45: Roundtable: The Religious Conscience in Modernity:
1) Nathan Chapman, Executive Director of the Stanford Constitutional Law Center who joined the Law School as a Fellow in 2010. After clerking for the Honorable Judge Gerald Bard Tjoflat on the United States Court of Appeals for the Eleventh Circuit Court, he practiced with WilmerHale in Washington, D.C. He graduated from Duke University School of Law and Duke Divinity School in 2007. His most recent publications include Disentangling Conscience and Religion, 2013 U. Ill. L. Rev. (forthcoming) and Due Process As Separation of Powers, 121 Yale L. J. 1672 (2012) (with Michael W. McConnell).
2) Steven Knapp, President of the George Washington University since August 2007, former Dean of Arts and Sciences and subsequently Provost at Johns Hopkins University, and Professor of English at UC Berkeley. Author most recently with Philip Clayton of The Predicament of Belief: Science, Philosophy, Faith. A specialist in Romanticism, literary theory, and the relation of literature to philosophy and religion, Dr. Knapp earned his doctorate and masters degrees from Cornell University and his Bachelor of Arts degree from Yale University.
3) Arnold Eisen, Chancellor, Jewish Theological Seminary, NYC. Author most recently of Rethinking Modern Judaism: Ritual, Commandment, Community and Taking Hold of Torah: Jewish Commitment and Community in America.
Stanford Moderator: Nancy Ruttenburg, William Robertson Coe Professor of American Literature, Professor by Courtesy of Comparative Literature and Slavic, Director, Stanford Center for the Study of the Novel
- 5:00 – 7:00: Conscience/Ethics: The Secular Conscience
1) Jay M. Bernstein, University Distinguished Professor, New School for Social Research. Author most recently of Against Voluptuous Bodies: Adorno’s Late Modernism and the Meaning of Painting; Adorno: Disenchantment and Ethics; and a co-authored volume published through UC Berkeley’s Townsend Center entitled Art and Aesthetics After Adorno.
2) Kent Greenawalt, University Professor, former Editor-in-Chief of the Columbia Law Review, Columbia Law School. Author, among many other works, of Religion and the Constitution: Vol. I: Free Exercise and Fairness and Vol. II: Establishment and Fairness, as well as Does God Belong in Public Schools? and Private Consciences and Public Reasons.
Stanford Respondent: Nancy Ruttenburg, William Robertson Coe Professor of American Literature, Professor by Courtesy of Comparative Literature and Slavic, Director of Stanford Center for the Study of the Novel
Friday, November 9, 9:00 a.m. - 6:45 p.m.
Contemporary Casuistry: Cases of Conscience in Action
Friday Morning Panels: Narrating Conscience: Modes of Witnessing
- 9:00 – 11:00: Conscience and Reportage
1) Dr. Sheri Fink, M.D., Ph.D., 2010 Pulitzer Prize- and National Magazine Award-winner in investigative journalism for “The Deadly Choices at Memorial” about difficult choices made at a New Orleans hospital during the aftermath of Katrina; contributor to ProPublica who has reported globally on health, medicine, and science; senior fellow with the New America Foundation and the Harvard Humanitarian Initiative; author of War Hospital: A True Story of Surgery and Survival (2003) during the Balkan crisis, winner of the American Medical Writer’s Association special book award and finalist for PEN Martha Albrand awards.
2) Colin Dayan, Robert Penn Warren Professor in the Humanities, Vanderbilt, and expert in literary, legal, and religious studies of the Americas; books include Haiti, History, and the Gods (1998); The Story of Cruel and Unusual (2007); and, most recently, The Law is a White Dog: How Legal Rituals Make and Unmake Persons, selected as a Choice top-25 "outstanding academic book of 2011."
Stanford Respondent: David Palumbo-Liu, Louise Hewlett Nixon Professor, Professor of Comparative Literature, Professor by courtesy of English
- 11:15 – 1:15: Roundtable: Embodied Conscience
1) Dr. Abraham Verghese, author of the novel Cutting for Stone (2010)as well as the non-fiction works, My Own Country: A Doctor’s Story (1995)about his experience as a physician working in rural Tennessee at the beginning of the AIDS crisis, and The Tennis Partner: A Story of Friendship and Loss (1998). Currently Professor for the Theory and Practice of Medicine and Senior Associate Chair of the Department of Internal Medicine, Stanford.
2) Mark Johnson, Philip H. Knight Professor of Liberal Arts and Sciences, Department of Philosophy, University of Oregon. Author most recently of The Meaning of the Body: Aesthetics of Human Understanding, Philosophy in the Flesh: The Embodied Mind and its Challenge to Western Thought (co-authored with George Lakoff); Moral Imagination: Implications of Cognitive Science for Ethics; and a second edition of Metaphors We Live By (co-authored with George Lakoff).
3) Dr. Fady Joudah, Internal Medicine and Palestinian-American poet; former practitioner with Doctors Without Borders in Darfur, Sudan and Zambia; translator of the poetry of Mahmoud Darwish and Ghassan Zaqtan, and 2007 winner of the Yale Series of Younger Poets Competition for The Earth in the Attic (2008).
Stanford Moderator: Blakey Vermeule, Professor of English
Friday Afternoon Panels: Conscience in the World: Problems of Toleration and Intervention
- 2:30 – 4:30: Roundtable: Conscientious Objection
1) Air Force Reserve Col. Steven Kleinman, Senior Intelligence Officer, U.S. Air Force; a widely recognized subject matter expert with extensive experience in human intelligence operations, special operations, strategic interrogation, and resistance to interrogation; Senior Advisor to the Intelligence Science Board’s study “Educing Information” which issued guidelines for improving the government’s interrogation techniques. Publicly opposed “enhanced interrogation” techniques for battling the war on terror in testimony before the Senate Armed Services Committee, the Senate Select Committee on Intelligence, and the House Judiciary Committee. Authored numerous articles laying out his argument against torture published in several peer-reviewed professional journals, the law review of the City University of New York and Valparaiso University law schools, and the Nieman Foundation for Journalism at Harvard.
2) Eyal Press, author of Beautiful Souls: Saying No, Breaking Ranks, and Heeding the Voice of Conscience in Dark Times and Absolute Convictions; contributor to several journals, including The Nation, The New York Review of Books, The New York Times Magazine, Mother Jones, The Atlantic Monthly, and others.
3) Yusef Komunyakaa: Global Distinguished Professor of English, NYU, Vietnam veteran and Pulitzer Prize-winning poet whose collections include The Chameleon Couch, Taboo: The Wishbone Trilogy, Pleasure Dome and many others.
Stanford Moderator: Debra Satz, Associate Dean of Humanities, Marta Sutton Weeks Professor of Ethics in Society; Professor of Philosophy and by courtesy Political Science; Research Affiliate, Program on Global Justice
4:45 – 6:45: KEYNOTE ADDRESS: ANNE AGHION
For her work on the gacaca trials in post-genocide Rwanda, documentary filmmaker Anne Aghion won the UNESCO Fellini Prize, an Emmy Award, the Human Rights Watch 2009 Nestor Almendros Prize, and she was a nominee for the 2009 Gotham Award. Her feature-length documentary, My Neighbor, My Killer, was one of the few documentaries to be an Official Selection at the Cannes Film Festival.
Bechtel Conference Center
Wer hilft den Opfern?
Der diesjährige "Freedom in the World"-Bericht des Forschungsinstituts "Freedom House" weist bereits zum fünften Jahr in Folge auf einen alarmierenden Rückgang von Freiheit, Demokratie und Achtung der Menschenrechte weltweit hin. Während die Menschenrechte in den Diktaturen in Nordkorea, im Iran, in Syrien, Libyen und China mit Füßen getreten werden, dominieren den außenpolitischen Diskurs in Europa vor allem zwei Themen: die israelische Blockade des Gazastreifens und der von den USA geführte Krieg gegen Terror.
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes
Abstract:
Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced β cell exocytosis. In this locus, Adra2a, encoding the alpha2A-adrenergic receptor [alpha(2A)AR], was significantly overexpressed. Alpha(2A)AR mediates adrenergic suppression of insulin secretion. Pharmacological receptor antagonism, silencing of receptor expression, or blockade of downstream effectors rescued insulin secretion in congenic islets. Furthermore, we identified a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk. Human pancreatic islets from risk allele carriers exhibited reduced granule docking and secreted less insulin in response to glucose; both effects were counteracted by pharmacological alpha(2A)AR antagonists.